Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study

Abstract Objective In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine cysteine restriction enriched in PUFA (Met/Cys low + PUFA, n = 7) or high contents of methionine, SFA SFA, 7). The objective was describe the short-term responses oral glucose tolerance, amino acid profile, total fatty pyruvate lactate following Met/Cys diet vs. SFA. Results groups consisted five two men, aged 20–38 years. After 7-d median pre- post-oral tolerance test (OGTT) concentrations were 5 mmol/L 4 respectively group. group, post-OGTT 4.8 4.65 after intervention. profiles similar both during exception serine. Fatty acids decreased from baseline day 7 groups. Plasma for an increase 3 before approaching values at 7. Trial registration ClinicalTrials.gov: NCT02647970, date: January 6 th 2016.